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Noribogaine also elevates serotonin concentrations inside the brain, a doable rationalization for its antidepressive effects. The sustained presence of noribogaine inside the CNS coupled with its agonist action at opioid receptors may well deliver the self-tapering effect in opiate-dependent individuals read more adhering to abrupt discontinuation of opiates. In addition, ibogaine has the capacity to alter the expression of numerous proteins, material P, and brain-derived neurotrophic element. Noribogaine may very well be a lot less neurotoxic than ibogaine.Litjens 2016
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